Demenidazole, a matsayin ƙarni na farko na magungunan ƙwayoyin cuta na antigenic, ƙananan farashin sa ya sa yadu amfani da shi a cikin ganewar asibiti na asibiti da magani.Duk da haka, tare da yawan amfani da irin wannan nau'in magunguna da kuma koma baya da kuma farkon ƙarni na nitroimidazoles, matsalar juriya na miyagun ƙwayoyi a cikin aikace-aikacen za ta zama mafi girma.

01Anti anaerobic sakamako

Koyaya, aikace-aikacensa mai fa'ida a cikin kiwon kaji yana nunawa a cikin ƙwayoyin cutar anaerobic.A cikin shekarun da suka gabata, an yi amfani da shi sosai a cikin maganin ciwon daji na necrotic na kaji, ciwo na enterotoxic da kumburi na oviduct.Duk da haka, hankalinsa ga anaerobes yana daɗa muni da muni.Dalili kuwa shi ne: da dadewa a baya, cin zarafi da amfani da shi ba bisa ka'ida ba ya haifar da karuwar juriyar kwayoyin cutar anaerobic iri-iri a kowace shekara, kuma ana ci gaba da sa ido.Domin dakile wannan mummunan yanayin ci gaba, sashen kwararrun likitocin dabbobi ya fito karara ya haramta shi fiye da shekaru goma da suka gabata: ana iya amfani da shi ne kawai wajen kiwo da samar da dabbobin abinci da aka fi amfani da su, kuma za a iya amfani da su ne kawai a ciki. da kiwon dabbobi da kaji, dabbobin gida da wasu marasa abinci na musamman kiwo.

02Daidaituwar kimiyya da ma'ana

A cikin yanayin dacewa da rashin amfani da demenidazole, da farko, bai kamata a yi amfani da shi tare da methamphenicol, florfenicol da sauran maganin rigakafi na amido barasa ba, saboda demenidazole na iya haifar da dysplasia na kasusuwa a cikin dabbobi da kaji, da kuma lokacin amfani da shi tare da abin da ke sama. amido barasa maganin rigakafi, zai kara hadarin m halayen a cikin jini tsarin.

Abu na biyu, bai kamata a yi amfani da shi tare da ethanol ko shirye-shirye dauke da adadi mai yawa na ethanol ba, saboda haɗuwa da su biyun zai haifar da amsawar disulfiram, kuma dabbobin da ba su da lafiya suna iya samun wasu alamun cututtuka na jijiyoyi.Bugu da ƙari, yin amfani da barasa ko magungunan da ke dauke da barasa mai yawa ya kamata a rage shi sosai a cikin kwanaki 7-10 bayan janyewar miyagun ƙwayoyi.

Na uku, galibi ga masana'antar likitancin dabbobi, na farko, bai kamata a haɗa shi da magungunan rigakafi ba, in ba haka ba, demenidazole na iya hana tasirin mycophenolate mofetil a jiki.Na biyu, ba za a iya amfani da shi tare da magungunan kashe jini na baki, wanda zai inganta tasirin anticoagulant na maganin maganin jini na baki kamar warfarin, ta yadda dabbobin gida suna da haɗarin zubar jini.

A ƙarshe, wannan ya fi girma a cikin masana'antar likitancin dabbobi.Na farko, ba za a iya haɗa shi tare da masu hana ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba.Alal misali, masu hana ƙwayoyin enzyme na hanta irin su cimetidine na iya hana ƙwayar metronidazole.Lokacin da aka haɗe, ya zama dole don gano ƙwayar magungunan jini kuma daidaita kashi nan da nan.Na biyu shi ne cewa ba za a iya amfani da shi tare da hepatic miyagun ƙwayoyi enzyme inducers.Lokacin da aka haɗe tare da hanta miyagun ƙwayoyi enzyme inducers kamar phenytoin, da metabolism na demenidazole za a kara hanzari da kuma plasma taro za a rage;Metabolism na phenytoin da sauran masu haifar da enzyme na hanta na hanta ya ragu kuma an ƙara yawan ƙwayar plasma.

03Shirye-shiryen yana rinjayar tasirin curative

Saboda demenidazole kanta yana da ɗan narkewa a cikin ruwa kuma yana da maganin rigakafi na lokaci-lokaci, lahaninsa na miyagun ƙwayoyi da halayen pharmacodynamic sun ƙayyade cewa "shiri yana ƙayyade inganci".Mu sau da yawa gani a cikin ciyawa-tushen raka'a cewa solubility na dimenidazole premix samfurin ne musamman matalauta.Bayan ƙara ruwa mai yawa da kuma haɗuwa sosai, akwai "yawan adadin abubuwa marasa narkewa" a cikin samfurin yashi mai kyau.Wannan ba ainihin “sophistry” na masana'anta ba ne don kiran matsalar ingancin ruwa, ko da'awar ƙarya cewa abubuwan da ba za a iya narkewa su ne abubuwan haɓakawa da sauran abubuwan da ba na ƙwayoyi ba.

Duk irin waɗannan samfuran na dimenidazole, ban da mai rahusa da rahusa, an haɗa su "babu wani tasiri".

Sabili da haka, yawancin manoma masu ciyawa da masu amfani da magungunan dabbobi ya kamata su kula da samfuran "masu inganci" tare da isasshen abun ciki na miyagun ƙwayoyi da kuma solubility mai kyau lokacin zaɓar samfuran premix na dimenidazole don maganin cututtukan anaerobic a cikin tsarin narkewa ko tsarin haihuwa.Baya ga zaɓi na kwayoyi, mataki mafi mahimmanci shine: bisa ga haƙiƙanin haƙiƙa na haɓaka juriya na miyagun ƙwayoyi, yakamata mu yi aiki mai kyau a cikin haɗin gwiwa, haɗin gwiwa da yin amfani da juriya na maganin miyagun ƙwayoyi, don haɓakawa da yin la'akari da "inganci" maganin miyagun ƙwayoyi.