Sulfonamides suna da fa'idodi na bakan ƙwayoyin cuta mai faɗi, kaddarorin barga, ƙarancin farashi da shirye-shiryen da yawa don zaɓar daga. Tsarin asali na sulfonamides shine p-sulfanilamide. Yana iya tsoma baki tare da kira na folic acid na kwayan cuta kuma yana shafar girma da haifuwa, ta haka ne ya hana yawancin kwayoyin cutar Gram-positive da wasu ƙwayoyin cuta mara kyau.

Kwayoyin da suke da matukar damuwa ga sulfa sun hada da: Streptococcus, Pneumococcus, Salmonella, da dai sauransu, kuma masu matsakaicin hankali sune: Staphylococcus, Escherichia coli, Pasteurella, Shigella, Listeria, wasu Actinomyces da Treponema hyodysenteriae Har ila yau suna kula da sulfonamides; Hakanan yana da tasiri akan wasu protozoa kamar coccidia. Bacteria masu kula da sulfonamides na iya haɓaka juriya.

A cikin ainihin amfani, sulfonamides galibi ana amfani da su tare da wasu magunguna. Mafi yawan illolin amfani da dogon lokaci na farkon sulfonamides sune rikicewar tsarin urinary, raunin koda da rage cin abinci.

Domin rage yawan guba da illolinsa, da farko, adadin ya kamata ya dace, kuma kada a ƙara ko rage shi yadda ake so. Idan adadin ya yi girma sosai, zai kara yawan guba da sakamako masu illa, kuma idan adadin ya yi ƙanƙara, ba kawai zai sami sakamako na warkewa ba, amma zai haifar da ƙwayoyin cuta don haɓaka juriya na miyagun ƙwayoyi. Na biyu, yi amfani da wasu kwayoyi, irin su amproline da sulfonamide synergists, don rage sashi. Na uku, idan dabara ta ba da izini, ana iya ƙara daidai adadin sodium bicarbonate. Na hudu, kwayoyin cuta na iya samar da nau'i daban-daban na juriya ga magungunan sulfa, don haka lokacin da suke jure wa wani maganin sulfa, bai dace a canza zuwa wani maganin sulfa ba. Gabaɗaya magana, adadin farko na magungunan sulfa dole ne a ninka sau biyu, kuma bayan lokaci mai tsanani, yakamata a dage da shan maganin na tsawon kwanaki 3-4 kafin a daina.